Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

BackgroundThe significance of brain angiotensin II in Alzheimer disease (AD) is unclear. Methods and ResultsTo examine the role of brain angiotensin II in AD, intracerebroventricular angiotensin II infusion was performed on 5XFAD mice, a mouse model of AD, and wild‐type mice, and the detrimental eff...

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Bibliographic Details
Main Authors: Koki Takane, Yu Hasegawa, Bowen Lin, Nobutaka Koibuchi, Cheng Cao, Takashi Yokoo, Shokei Kim‐Mitsuyama
Format: Article
Language:English
Published: Wiley 2017-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Alzheimer disease
angiotensin II
cerebrovascular disease
cognitive impairment
dementia
sarcopenia
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004897

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.004897

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