Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last f...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267697/full |
| _version_ | 1797674048995459072 |
|---|---|
| author | Edgar Angelats Pere Santamaria Pere Santamaria |
| author_facet | Edgar Angelats Pere Santamaria Pere Santamaria |
| author_sort | Edgar Angelats |
| collection | DOAJ |
| description | T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny. |
| first_indexed | 2024-03-11T21:54:30Z |
| format | Article |
| id | doaj.art-2efc782ff9904353b7c69e07ff36d616 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T21:54:30Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2efc782ff9904353b7c69e07ff36d6162023-09-26T04:56:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12676971267697Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cellsEdgar Angelats0Pere Santamaria1Pere Santamaria2Pathogenesis and Treatment of Autoimmunity Group, Institut D’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainPathogenesis and Treatment of Autoimmunity Group, Institut D’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaT Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267697/fullautoimmunityT-regulatory (Treg) cellsT-regulatory type 1 (TR1) cellspeptide-MHCnanomedicineT-follicular helper cells (Tfh) |
| spellingShingle | Edgar Angelats Pere Santamaria Pere Santamaria Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells Frontiers in Immunology autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh) |
| title | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
| title_full | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
| title_fullStr | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
| title_full_unstemmed | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
| title_short | Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells |
| title_sort | lineage origin and transcriptional control of autoantigen specific t regulatory type 1 cells |
| topic | autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267697/full |
| work_keys_str_mv | AT edgarangelats lineageoriginandtranscriptionalcontrolofautoantigenspecifictregulatorytype1cells AT peresantamaria lineageoriginandtranscriptionalcontrolofautoantigenspecifictregulatorytype1cells AT peresantamaria lineageoriginandtranscriptionalcontrolofautoantigenspecifictregulatorytype1cells |