Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke

Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke

Abstract Background Activation of transforming growth factor-β-activated kinase 1 (TAK1) occurs after stroke and leads to an exacerbation of brain injury. TAK1 is involved in innate and adaptive immune responses, but it has divergent inflammatory effects that are dependent on the cell type in which...

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Bibliographic Details
Main Authors: Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C. Koellhoffer, Anthony Patrizz, Rodney M. Ritzel, Bhanu P. Ganesh, Louise D. McCullough
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Monocytes
Neutrophils
Inflammation
TAK1
Online Access:http://link.springer.com/article/10.1186/s12974-018-1188-3

Internet

http://link.springer.com/article/10.1186/s12974-018-1188-3

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