The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue

The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue

Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We report that subretinal transplantation of RPE stem c...

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Bibliographic Details
Main Authors: Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Müller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, Jeffrey H. Stern
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
retinal pigment epithelium
RPE
stem cell
transplant
differentiation stage
macular degeneration
AMD
developmental stage
vision rescue
RPE transplant efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302230

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http://www.sciencedirect.com/science/article/pii/S2213671117302230

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