Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.

Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.

The antibody response to influenza infection is largely dependent on CD4 T cell help for B cells. Cognate signals and secreted factors provided by CD4 T cells drive B cell activation and regulate antibody isotype switching for optimal antiviral activity. Recently, we analyzed HLA-DR1 transgenic (DR1...

Full description

Bibliographic Details
Main Authors: Aarthi Sundararajan, Lifang Huan, Katherine A Richards, Glendie Marcelin, Shabnam Alam, Hyemee Joo, Hongmei Yang, Richard J Webby, David J Topham, Andrea J Sant, Mark Y Sangster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3311631?pdf=render

Internet

http://europepmc.org/articles/PMC3311631?pdf=render

Similar Items