A Mechanism Underlying Attenuation of Recombinant Influenza A Viruses Carrying Reporter Genes

A Mechanism Underlying Attenuation of Recombinant Influenza A Viruses Carrying Reporter Genes

Influenza A viruses (IAV) carrying reporter genes provide a powerful tool to study viral infection and pathogenesis in vivo, however, incorporating a non-essential gene into the IAV genome often results in virus attenuation and genetic instability. Very few studies have systematically compared diffe...

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Bibliographic Details
Main Authors: Xiujuan Zhao, Lin Wang, Qinghua Cui, Ping Li, Yanyan Wang, Yingying Zhang, Yong Yang, Lijun Rong, Ruikun Du
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Viruses
Subjects:
influenza A virus
reporter virus
attenuation
mechanism
noninfectious particles
vRNA replication
Online Access:https://www.mdpi.com/1999-4915/10/12/679

Internet

https://www.mdpi.com/1999-4915/10/12/679

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