The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

Finasteride (Fin) causes androgen imbalance by inhibiting the conversion of testosterone (T) to its more active metabolite, dihydrotestosterone (DHT). Androgen receptors (AR) are present (e.g., in hepatocytes), which have well-developed endoplasmic reticulum (ERet). Cellular protein quality control...

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Dades bibliogràfiques
Autors principals: Sylwia Rzeszotek, Agnieszka Kolasa, Anna Pilutin, Kamila Misiakiewicz-Has, Katarzyna Sielatycka, Barbara Wiszniewska
Format: Article
Idioma:English
Publicat: MDPI AG 2022-10-01
Col·lecció:Biomedicines
Matèries:
finasteride
androgen imbalance
androgen receptor
endoplasmic reticulum stress
oxidative stress
liver
Accés en línia:https://www.mdpi.com/2227-9059/10/11/2725

Internet

https://www.mdpi.com/2227-9059/10/11/2725

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