The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

Finasteride (Fin) causes androgen imbalance by inhibiting the conversion of testosterone (T) to its more active metabolite, dihydrotestosterone (DHT). Androgen receptors (AR) are present (e.g., in hepatocytes), which have well-developed endoplasmic reticulum (ERet). Cellular protein quality control...

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Hlavní autoři: Sylwia Rzeszotek, Agnieszka Kolasa, Anna Pilutin, Kamila Misiakiewicz-Has, Katarzyna Sielatycka, Barbara Wiszniewska
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2022-10-01
Edice:Biomedicines
Témata:
finasteride
androgen imbalance
androgen receptor
endoplasmic reticulum stress
oxidative stress
liver
On-line přístup:https://www.mdpi.com/2227-9059/10/11/2725

Internet

https://www.mdpi.com/2227-9059/10/11/2725

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