Inhibition of Wnt pathway activity as a treatment approach for human osteoarthritis: a systematic review

Inhibition of Wnt pathway activity as a treatment approach for human osteoarthritis: a systematic review

Background: Osteoarthritis (OA) is a chronic, degenerative condition associated with joint pain and disability. Because Wnt pathway signaling activity is abnormally upregulated in preclinical OA models, its inhibition is a target for disease-modifying OA drugs. Objectives: The literature was systema...

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Bibliographic Details
Main Authors: Eli T. Sayegh, Molly Zgoda, Chilan B.G. Leite, Andrea C. Carrano, Jeyanesh Tambiah, Christian Lattermann
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Cartilage & Joint Preservation
Subjects:
Arthritis
Animal models
Β-catenin
Human
Osteoarthritis
Wnt
Online Access:http://www.sciencedirect.com/science/article/pii/S2667254522000324

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http://www.sciencedirect.com/science/article/pii/S2667254522000324

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