AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies

AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak androgens, estrone (a weak estrogen), and PGD2 into potent...

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Bibliographic Details
Main Authors: Mengnan Li, Limin Zhang, Jiahui Yu, Xiaoxiao Wang, Le Cheng, Zhaowu Ma, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
AKR1C3
carcinoma progression
therapeutic resistance
inhibitors
combination therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1378292/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1378292/full

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