Effects of Deacetylase Inhibition on the Activation of the Antioxidant Response and Aerobic Metabolism in Cellular Models of Fanconi Anemia

Effects of Deacetylase Inhibition on the Activation of the Antioxidant Response and Aerobic Metabolism in Cellular Models of Fanconi Anemia

Fanconi anemia (FA) is a rare genetic disease characterized by a dysfunctional DNA repair and an oxidative stress accumulation due to defective mitochondrial energy metabolism, not counteracted by endogenous antioxidant defenses, which appear down-expressed compared to the control. Since the antioxi...

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Bibliographic Details
Main Authors: Nadia Bertola, Stefano Regis, Silvia Bruno, Andrea Nicola Mazzarello, Martina Serra, Michela Lupia, Federica Sabatini, Fabio Corsolini, Silvia Ravera, Enrico Cappelli
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
catalase
glutathione reductase
oxidative phosphorylation
lipid peroxidation
aldehyde dehydrogenase
energy metabolism
Online Access:https://www.mdpi.com/2076-3921/12/5/1100

Internet

https://www.mdpi.com/2076-3921/12/5/1100

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