Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Alzheimer’s disease (AD) has no cure. Earlier, we showed that partial inhibition of mitochondrial complex I (MCI) with the small molecule CP2 induces an adaptive stress response, activating multiple neuroprotective mechanisms. Chronic treatment reduced inflammation, Aβ and pTau accumulation, improve...

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Bibliographic Details
Main Authors: Jessica Panes, Thi Kim Oanh Nguyen, Huanyao Gao, Trace A. Christensen, Andrea Stojakovic, Sergey Trushin, Jeffrey L. Salisbury, Jorge Fuentealba, Eugenia Trushina
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
Alzheimer’s disease (AD)
mitochondria
endoplasmic reticulum (ER)
serial block-face scanning electron microscopy (SBFSEM)
three-dimensional electron microscopy (3DEM)
small molecule mitochondria targeted therapeutics
Online Access:https://www.mdpi.com/2073-4409/12/8/1111

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https://www.mdpi.com/2073-4409/12/8/1111

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