Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse

Abstract Background Phosphorus cardiovascular magnetic resonance spectroscopy (31P-CMRS) has emerged as an important tool for the preclinical assessment of myocardial energetics in vivo. However, the high rate and diminutive size of the mouse heart is a challenge, resulting in low resolution and poo...

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Bibliographic Details
Main Authors: Mahon L. Maguire, Debra J. McAndrew, Hannah A. Lake, Philip J. Ostrowski, Sevasti Zervou, Stefan Neubauer, Craig A. Lygate, Jurgen E. Schneider
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Journal of Cardiovascular Magnetic Resonance
Subjects:
31P-CMRS
Creatine kinase
Creatine transporter
Myocardial function
Transgenic mice
Energetics
Online Access:https://doi.org/10.1186/s12968-023-00911-6

Internet

https://doi.org/10.1186/s12968-023-00911-6

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