Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line

Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line

ABSTRACT Nonribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs) play a pivotal role in the production of bioactive natural products, such as antibiotics and cytotoxins. Despite biomedical and pharmaceutical importance, the molecular mechanisms and architectures of these multimodu...

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Bibliographic Details
Main Authors: A. Gacek-Matthews, Z. Chromiková, M. Sulyok, G. Lücking, I. Barák, M. Ehling-Schulz
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
Bacillus cereus
cereulide
ABC transporter
nonribosomal peptide synthetases (NRPS)
bacterial adenylate cyclase-based two-hybrid system (BACTH)
Online Access:https://journals.asm.org/doi/10.1128/mBio.01577-20

Internet

https://journals.asm.org/doi/10.1128/mBio.01577-20

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