Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial

Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial

The RTS,S candidate malaria vaccine can protect against controlled human malaria infection (CHMI), but how protection is achieved remains unclear. Here, we have analyzed longitudinal peripheral blood transcriptome and immunogenicity data from a clinical efficacy trial in which healthy adults receive...

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Bibliografiska uppgifter
Huvudupphovsmän: Robert A. van den Berg, Margherita Coccia, W. Ripley Ballou, Kent E. Kester, Christian F. Ockenhouse, Johan Vekemans, Erik Jongert, Arnaud M. Didierlaurent, Robbert G. van der Most
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2017-05-01
Serie:Frontiers in Immunology
Ämnen:
malaria
systems biology
transcriptome
vaccine
clinical trial
interferon gamma
Länkar:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00557/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00557/full

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