The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration

Retinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affecting people worldwide, and is currently incurable. It is characterized by the progressive loss of photoreceptors, in which the death of rod cells leads to the secondary death of cone cells; the cause of eventual...

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Bibliographic Details
Main Authors: Ashleigh M. Byrne, Ana M. Ruiz-Lopez, Sarah L. Roche, Jennifer N. Moloney, Alice C. Wyse -Jackson, Thomas G. Cotter
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716301112