A Small Ligand That Selectively Binds to the G-quadruplex at the Human Vascular Endothelial Growth Factor Internal Ribosomal Entry Site and Represses the Translation

A Small Ligand That Selectively Binds to the G-quadruplex at the Human Vascular Endothelial Growth Factor Internal Ribosomal Entry Site and Represses the Translation

G-quadruplexes are believed to have important biological functions, so many small molecules have been screened or developed for targeting G-quadruplexes. However, it is still a major challenge to find molecules that recognize specific G-quadruplexes. Here, by using a combination of surface plasmon r...

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Bibliographic Details
Main Authors: Xiao-Xia Hu, Sheng-Quan Wang, Shi-Quan Gan, Lei Liu, Ming-Qing Zhong, Meng-Hao Jia, Fei Jiang, Yan Xu, Chao-Da Xiao, Xiang-Chun Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Chemistry
Subjects:
G-quadruplex
VEGF
selective ligand
translation
RNA
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.781198/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.781198/full

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