Detection and quantification of mitochondrial DNA deletions from next-generation sequence data

Detection and quantification of mitochondrial DNA deletions from next-generation sequence data

Abstract Background Chromosomal deletions represent an important class of human genetic variation. Various methods have been developed to mine “next-generation” sequencing (NGS) data to detect deletions and quantify their clonal abundances. These methods have focused almost exclusively on the nuclea...

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Bibliographic Details
Main Authors: Colleen M. Bosworth, Sneha Grandhi, Meetha P. Gould, Thomas LaFramboise
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Bioinformatics
Subjects:
Next-generation sequencing
Mitochondria DNA
Human genome
Chromosomal deletions
Online Access:http://link.springer.com/article/10.1186/s12859-017-1821-7

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http://link.springer.com/article/10.1186/s12859-017-1821-7

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