Viral delivery of a peptide-based immunomodulator enhances T cell priming during vaccination

Viral delivery of a peptide-based immunomodulator enhances T cell priming during vaccination

Modern, subunit-based vaccines have so far failed to induce significant T cell responses, contributing to ineffective vaccination against many pathogens. Importantly, while today’s adjuvants are designed to trigger innate and non-specific immune responses, they fail to directly stimulate the adaptiv...

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Bibliographic Details
Main Authors: Timothy W. Phares, Jing Huang, Vinayaka Kotraiah, Mary J. Hauser, Arban Domi, Sreenivasa Oruganti, Cecille D. Browne, Peter Buontempo, Marc Mansour, James Pannucci, Moriya Tsuji, Gabriel M. Gutierrez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
vaccine
PD1
immunomodulator
CD8+
viral delivery
infectious disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1029636/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1029636/full

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