Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease

Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease

Abstract Background Hyperhomocysteinemia (HHcy) has been linked to development of Alzheimer’s disease (AD) neuropathologically characterized by the accumulation of amyloid β (Aβ). Microglia (MG) play a crucial role in uptake of Aβ fibrils, and its dysfunction worsens AD. However, the effect of HHcy...

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Bibliographic Details
Main Authors: Xianwei Wang, Lu Liu, Xiaohua Jiang, Jason Saredy, Hang Xi, Ramon Cueto, Danni Sigler, Mohsin Khan, Sheng Wu, Yong Ji, Nathaniel W. Snyder, Wenhui Hu, Xiaofeng Yang, Hong Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s
Hyperhomocysteinemia
Microglia
Phagocytosis
Hypomethylation
Amyloid β
Online Access:https://doi.org/10.1186/s13195-023-01311-9

Internet

https://doi.org/10.1186/s13195-023-01311-9

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