GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset

GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset

Enhanced spontaneous GABAA receptor activity is associated with focal cortical dysplasia (FCD), a developmental malformation of the cerebral cortex. Clinical manifestations in FCD vary with age at epilepsy onset with a more favorable prognosis in patients with late-onset (LO) compared to that in cas...

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Bibliographic Details
Main Authors: Jyotirmoy Banerjee, Soumil Dey, Aparna Banerjee Dixit, Ramesh Doddamani, Meher Chand Sharma, Ajay Garg, P. Sarat Chandra, Manjari Tripathi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
drug-resistant epilepsy
GABAergic activity
electrocorticography (ECoG)
resected brain sample
patch-clamp technique
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.562811/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.562811/full

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