Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

Full description

Bibliographic Details
Main Authors: Yusuke Oku, Naoyuki Nishiya, Toshiya Shito, Reiichiro Yamamoto, Yasufumi Yamamoto, Chihiro Oyama, Yoshimasa Uehara
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
YAP
TAZ
Statins
Dasatinib
Pazopanib
Combination therapy
Online Access:https://doi.org/10.1016/j.fob.2015.06.007

Internet

https://doi.org/10.1016/j.fob.2015.06.007

Similar Items