Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents

A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins <b>3a–f</b> (isatin, <b>3a</b>, 6-chloroisatin, <b>3b</b>, 5-fluoroi...

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Bibliographic Details
Main Authors: Abdullah Mohammed Al-Majid, M. Ali, Mohammad Shahidul Islam, Saeed Alshahrani, Abdullah Saleh Alamary, Sammer Yousuf, M. Iqbal Choudhary, Assem Barakat
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
spirooxindole
azomethine ylides
[3+2] cycloaddition reaction
anti-cancer activity
Online Access:https://www.mdpi.com/1420-3049/26/20/6305

Internet

https://www.mdpi.com/1420-3049/26/20/6305

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