Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen

Abstract Adjuvants can enhance vaccine immunogenicity, but their mechanism of action is often incompletely understood, hampering rapid applicability for pandemic vaccines. Herein, we characterized the cellular and molecular activity of adjuvant formulations available for pre-clinical evaluation, inc...

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Bibliographic Details
Main Authors: Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi, Célia Lebas, Floriane Auderset, Yamile Lugo-Rodriguez, Guzman Sanchez-Schmitz, David J. Dowling, Ofer Levy, Simon D. van Haren
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00759-y