Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists
Abstract Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal side effects, addiction, and opioid tolerance are extremely challenging. The development of novel molecules targeting the $$\mu$$ μ -opioid receptor (MOR) in inflamed, but not in healthy tissue, could s...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
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| Series: | Journal of Cheminformatics |
| Online Access: | https://doi.org/10.1186/s13321-023-00746-4 |