Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis

Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis

Abstract Background Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong patient survival. Alkaline phosphatase (ALPL), a homodimeric cell surface phosphohydrolase, is reported to play a contro...

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Bibliographic Details
Main Authors: Zhefeng Lou, Weiwei Lin, Huirong Zhao, Xueli Jiao, Cong Wang, He Zhao, Lu Liu, Yu Liu, Qipeng Xie, Xing Huang, Haishan Huang, Lingling Zhao
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer Cell International
Subjects:
ALPL
Lung adenocarcinoma (LUAD)
C-Myc degradation
RhoA
Metastasis
Online Access:https://doi.org/10.1186/s12935-021-01919-7

Internet

https://doi.org/10.1186/s12935-021-01919-7

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