SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction

Abstract Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases, such as psoriasis. SerpinB7 is identified as a skin-specific endogenous protease inhibitor, but the role and underlying mechanism in psoriasis...

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Bibliographic Details
Main Authors: Huaping Zheng, Linna Gu, Fulei Zhao, Chen Zhang, Zhen Wang, Hong Zhou, Zhonglan Hu, Xiaoqiong Wei, Xiao Liu, Feng Luo, Fanlian Zeng, Qixiang Zhao, Yan Hao, Yawen Hu, Xiaoyan Wang, Jing Hu, Jiadong Yu, Wenling Wu, Yifan Zhou, Pei Zhou, Chengcheng Yue, Nongyu Huang, Kaijun Cui, Wei Li, Jiong Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05045-8

Internet

https://doi.org/10.1038/s41419-022-05045-8

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