Homologous recombination repair gene mutations as a predictive biomarker for immunotherapy in patients with advanced melanoma

Homologous recombination repair gene mutations as a predictive biomarker for immunotherapy in patients with advanced melanoma

BackgroundNowadays, immunotherapy targeting immune checkpoint receptors is one of the cornerstones of systemic treatment in melanoma. Homologous recombination repair (HRR) is one of the DNA damage response (DDR) pathways, which has been proved to correlate with the efficacy of platinum-based chemoth...

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Bibliographic Details
Main Authors: Zhixuan You, Meng Lv, Xuanyu He, Yingqin Pan, Junfeng Ge, Xue Hu, Yating Zheng, Mengli Huang, Chengzhi Zhou, Changxuan You
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
HRR
anti-CTLA-4 therapy
TMB
DDR
immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.871756/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.871756/full

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