HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation

HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation

Abstract Methyltransferase-like protein 3 (METTL3) plays critical roles in acute myeloid leukemia (AML) progression, however, the mechanism of abnormal overexpression of METTL3 in AML remain elusive. In the current study, we uncovered that Yin Yang 1 (YY1) binds to the promoter region of METTL3 as a...

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Bibliographic Details
Main Authors: Meng Li, Mingying Li, Yuan Xia, Guosheng Li, Xiuhua Su, Dongmei Wang, Jingjing Ye, Fei Lu, Tao Sun, Chunyan Ji
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05435-y

Internet

https://doi.org/10.1038/s41419-022-05435-y

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