Small molecule inhibitors of the Dishevelled‐CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

Small molecule inhibitors of the Dishevelled‐CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

Abstract Bone anabolic agents promoting bone formation and rebuilding damaged bones would ideally overcome the limitations of anti‐resorptive therapy, the current standard prescription for osteoporosis. However, the currently prescribed parathyroid hormone (PTH)‐based anabolic drugs present limitati...

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Bibliographic Details
Main Authors: Hyun‐Yi Kim, Sehee Choi, Ji‐Hye Yoon, Hwan Jung Lim, Hyuk Lee, Jiwon Choi, Eun Ji Ro, Jung‐Nyoung Heo, Weontae Lee, Kyoung Tai No, Kang‐Yell Choi
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
CXXC5
Dishevelled
negative feedback regulation
osteoporosis
Wnt/β‐catenin pathway
Online Access:https://doi.org/10.15252/emmm.201505714

Internet

https://doi.org/10.15252/emmm.201505714

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