Research progress of indole-fused derivatives as allosteric modulators: Opportunities for drug development

Allosteric modulation is a direct and effective method for regulating the function of biological macromolecules, which play vital roles in various cellular activities. Unlike orthosteric modulators, allosteric modulators bind to sites distant from the protein's orthosteric/active site and can h...

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Bibliographic Details
Main Authors: Meng-Lan Luo, Qian Zhao, Xiang-Hong He, Xin Xie, Hong-Ping Zhu, Feng-Ming You, Cheng Peng, Gu Zhan, Wei Huang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003621