Oral priming with replicating adenovirus serotype 4 followed by subunit H5N1 vaccine boost promotes antibody affinity maturation and expands H5N1 cross-clade neutralization.

Oral priming with replicating adenovirus serotype 4 followed by subunit H5N1 vaccine boost promotes antibody affinity maturation and expands H5N1 cross-clade neutralization.

A Phase I trial conducted in 2009-2010 demonstrated that oral vaccination with a replication competent Ad4-H5 (A/Vietnam) vector with dosages ranging from 107-1011 viral particles was well tolerated. HA-specific T-cell responses were efficiently induced, but very limited hemagglutination-inhibiting...

Full description

Bibliographic Details
Main Authors: Surender Khurana, Elizabeth M Coyle, Jody Manischewitz, Lisa R King, Glenn Ishioka, Jeff Alexander, Jon Smith, Marc Gurwith, Hana Golding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0115476&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0115476&type=printable

Similar Items