Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp [version 3; peer review: 1 approved, 2 approved with reservations]

Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp [version 3; peer review: 1 approved, 2 approved with reservations]

Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Methods: Hence, this study aims to screen for natural products' structural analog...

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Bibliographic Details
Main Authors: Luis Daniel Goyzueta-Mamani, Mayron Antonio Candia Puma, Miguel Angel Chávez-Fumagalli, Haruna Luz Barazorda-Ccahuana, Daniela Pagliara Lage, Eduardo Antonio Ferraz Coelho, Camila Simões de Freitas, Grasiele de Sousa Vieria Tavares
Format: Article
Language:English
Published: F1000 Research Ltd 2023-07-01
Series:F1000Research
Subjects:
leishmaniasis
Leishmania arginase
computer-aided drug design
molecular dynamics simulation
antiprotozoal agents; drug discovery
eng
Online Access:https://f1000research.com/articles/12-93/v3

Internet

https://f1000research.com/articles/12-93/v3

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