Low T-cell reactivity to TDP-43 peptides in ALS

Low T-cell reactivity to TDP-43 peptides in ALS

BackgroundDysregulation of the immune system in amyotrophic lateral sclerosis (ALS) includes changes in T-cells composition and infiltration of T cells in the brain and spinal cord. Recent studies have shown that cytotoxic T cells can directly induce motor neuron death in a mouse model of ALS and th...

Full description

Bibliographic Details
Main Authors: Swetha Ramachandran, Veselin Grozdanov, Bianca Leins, Katharina Kandler, Simon Witzel, Medhanie Mulaw, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
amyotrophic lateral sclerosis
T cells
TDP-43
autoantibody
autoantigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193507/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193507/full

Similar Items