Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors
ABSTRACT We conducted a genome-wide CRISPR/Cas9 screen in suspension 293 F cells transduced with rAAV5. The highly selected genes revealed after two rounds of screening included the previously reported KIAA0319L, TM9SF2, and RNF121, along with a cluster of genes involved in glycan biogenesis, Golgi...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Jezik: | English |
Izdano: |
American Society for Microbiology
2025-01-01
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Serija: | mBio |
Teme: | |
Online dostop: | https://journals.asm.org/doi/10.1128/mbio.03268-24 |