Neurons Are a Primary Driver of Inflammation via Release of HMGB1
Recent data show that activation of nociceptive (sensory) nerves turns on localized inflammation within the innervated area in a retrograde manner (antidromically), even in the absence of tissue injury or molecular markers of foreign invaders. This neuroinflammatory process is activated and sustaine...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/10/2791 |
| _version_ | 1797514985883041792 |
|---|---|
| author | Huan Yang Ulf Andersson Michael Brines |
| author_facet | Huan Yang Ulf Andersson Michael Brines |
| author_sort | Huan Yang |
| collection | DOAJ |
| description | Recent data show that activation of nociceptive (sensory) nerves turns on localized inflammation within the innervated area in a retrograde manner (antidromically), even in the absence of tissue injury or molecular markers of foreign invaders. This neuroinflammatory process is activated and sustained by the release of neuronal products, such as neuropeptides, with the subsequent amplification via recruitment of immunocompetent cells, including macrophages and lymphocytes. High mobility group box 1 protein (HMGB1) is a highly conserved, well characterized damage-associated molecular pattern molecule expressed by many cells, including nociceptors and is a marker of inflammatory diseases. In this review, we summarize recent evidence showing that neuronal HMGB1 is required for the development of neuroinflammation, as knock out limited to neurons or its neutralization via antibodies ameliorate injury in models of nerve injury and of arthritis. Further, the results of study show that HMGB1 is actively released during neuronal depolarization and thus plays a previously unrecognized key etiologic role in the initiation and amplification of neuroinflammation. Direct targeting of HMGB1 is a promising approach for novel anti-inflammatory therapy. |
| first_indexed | 2024-03-10T06:39:17Z |
| format | Article |
| id | doaj.art-2f4f601079db41148e4b2b4c1a3ad0b8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:17Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2f4f601079db41148e4b2b4c1a3ad0b82023-11-22T17:49:14ZengMDPI AGCells2073-44092021-10-011010279110.3390/cells10102791Neurons Are a Primary Driver of Inflammation via Release of HMGB1Huan Yang0Ulf Andersson1Michael Brines2Institute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, 350 Community Drive, Manhasset, NY 11030, USADepartment of Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, 17176 Stockholm, SwedenInstitute for Bioelectronic Medicine, The Feinstein Institutes for Medical Research, 350 Community Drive, Manhasset, NY 11030, USARecent data show that activation of nociceptive (sensory) nerves turns on localized inflammation within the innervated area in a retrograde manner (antidromically), even in the absence of tissue injury or molecular markers of foreign invaders. This neuroinflammatory process is activated and sustained by the release of neuronal products, such as neuropeptides, with the subsequent amplification via recruitment of immunocompetent cells, including macrophages and lymphocytes. High mobility group box 1 protein (HMGB1) is a highly conserved, well characterized damage-associated molecular pattern molecule expressed by many cells, including nociceptors and is a marker of inflammatory diseases. In this review, we summarize recent evidence showing that neuronal HMGB1 is required for the development of neuroinflammation, as knock out limited to neurons or its neutralization via antibodies ameliorate injury in models of nerve injury and of arthritis. Further, the results of study show that HMGB1 is actively released during neuronal depolarization and thus plays a previously unrecognized key etiologic role in the initiation and amplification of neuroinflammation. Direct targeting of HMGB1 is a promising approach for novel anti-inflammatory therapy.https://www.mdpi.com/2073-4409/10/10/2791high mobility group box 1TRPV1nociceptioncytokineinflammationnerve injury |
| spellingShingle | Huan Yang Ulf Andersson Michael Brines Neurons Are a Primary Driver of Inflammation via Release of HMGB1 Cells high mobility group box 1 TRPV1 nociception cytokine inflammation nerve injury |
| title | Neurons Are a Primary Driver of Inflammation via Release of HMGB1 |
| title_full | Neurons Are a Primary Driver of Inflammation via Release of HMGB1 |
| title_fullStr | Neurons Are a Primary Driver of Inflammation via Release of HMGB1 |
| title_full_unstemmed | Neurons Are a Primary Driver of Inflammation via Release of HMGB1 |
| title_short | Neurons Are a Primary Driver of Inflammation via Release of HMGB1 |
| title_sort | neurons are a primary driver of inflammation via release of hmgb1 |
| topic | high mobility group box 1 TRPV1 nociception cytokine inflammation nerve injury |
| url | https://www.mdpi.com/2073-4409/10/10/2791 |
| work_keys_str_mv | AT huanyang neuronsareaprimarydriverofinflammationviareleaseofhmgb1 AT ulfandersson neuronsareaprimarydriverofinflammationviareleaseofhmgb1 AT michaelbrines neuronsareaprimarydriverofinflammationviareleaseofhmgb1 |