Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular <i>Mycobacterium</i> <i>tuberculosis</i>

Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular <i>Mycobacterium</i> <i>tuberculosis</i>

Granulysin is an antimicrobial peptide (AMP) expressed by human T-lymphocytes and natural killer cells. Despite a remarkably broad antimicrobial spectrum, its implementation into clinical practice has been hampered by its large size and off-target effects. To circumvent these limitations, we synthes...

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Bibliographic Details
Main Authors: Reiner Noschka, Fanny Wondany, Gönül Kizilsavas, Tanja Weil, Gilbert Weidinger, Paul Walther, Jens Michaelis, Steffen Stenger
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
tuberculosis
antimicrobial peptide
Granulysin
human
macrophages
Online Access:https://www.mdpi.com/1422-0067/22/16/8392

Internet

https://www.mdpi.com/1422-0067/22/16/8392

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