NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expression of these antigens—are protected from cytotoxic...

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Bibliographic Details
Main Authors: Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Systems biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224011350

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224011350

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