Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model

Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model

Background: Boron neutron capture therapy (BNCT) has been adapted to high-grade gliomas (HG); however, some gliomas are refractory to BNCT using boronophenylalanine (BPA). In this study, the feasibility of BNCT targeting the 18 kDa translocator protein (TSPO) expressed in glioblastoma and surroundin...

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Bibliographic Details
Main Authors: Hideki Kashiwagi, Yoshihide Hattori, Shinji Kawabata, Ryo Kayama, Kohei Yoshimura, Yusuke Fukuo, Takuya Kanemitsu, Hiroyuki Shiba, Ryo Hiramatsu, Toshihiro Takami, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Mitsunori Kirihata, Masahiko Wanibuchi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
boron neutron capture therapy (BNCT)
high-grade gliomas (HG)
18 kDa translocator protein (TSPO)
convection-enhanced delivery (CED)
DPA
Online Access:https://www.mdpi.com/2072-6694/15/4/1034

Internet

https://www.mdpi.com/2072-6694/15/4/1034

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