A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer

A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer

De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease, trials combining chemotherapy and an anti-EGFR monoclonal antibody have been largely unsuccessful. In an effort to iden...

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Bibliographic Details
Main Authors: Tianyu Cao, Yuanyuan Lu, Qi Wang, Hongqiang Qin, Hongwei Li, Hao Guo, Minghui Ge, Sarah E. Glass, Bhuminder Singh, Wenyao Zhang, Jiaqiang Dong, Feng Du, Airong Qian, Ye Tian, Xin Wang, Cunxi Li, Kaichun Wu, Daiming Fan, Yongzhan Nie, Robert J. Coffey, Xiaodi Zhao
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-03-01
Series:The Journal of Clinical Investigation
Subjects:
Gastroenterology
Oncology
Online Access:https://doi.org/10.1172/JCI154074

Internet

https://doi.org/10.1172/JCI154074

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