Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1

Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1

In this paper, we reported the hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester (DAE), a component of Ganoderma applanatum, in hyperuricemic mice through inhibiting XOD and down-regulating URAT1. Computationally, DAE showed a high similarity to allopurinol and depicted a high affinity i...

Full description

Bibliographic Details
Main Authors: Tianqiao Yong, Danling Liang, Chun Xiao, Longhua Huang, Shaodan Chen, Yizhen Xie, Xiong Gao, Qingping Wu, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hyperuricemia
2,4-dihydroxybenzoic acid methyl ester
Molecular docking
Xanthine oxidase
Uric acid transporter 1
Organic anion transporter 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222006928

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222006928

Similar Items