Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function

Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physi...

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Bibliographic Details
Main Authors: Nathan R. Kerr, Taylor J. Kelty, Xuansong Mao, Thomas E. Childs, David D. Kline, R. Scott Rector, Frank W. Booth
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1147420/full