Overexpression of miR-148a-3p inhibits extracellular matrix degradation and alleviates IL-1β-induced intervertebral disc degeneration

Overexpression of miR-148a-3p inhibits extracellular matrix degradation and alleviates IL-1β-induced intervertebral disc degeneration

Objective(s): Recently, studies on microRNAs (miRNAs) and their targets and related genes have provided new therapeutic opportunities for controlling intervertebral disc degeneration (IDD). We aimed to investigate the effects of miR-148a-3p overexpression on IDD progression.Materials and Methods: Th...

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Bibliographic Details
Main Authors: Hehuan Lai, Jialin Fan, Yejin Zhang, Bin Pan, Wenzheng Pan, Jiawei Fang, Kainan Ni, Zhenzhong Chen, Shijie Liu, Chao Lou, Dengwei He
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2023-02-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
extracellular matrix
intervertebral disc micrornas
mir-148a-3p
nucleus pulposus
Online Access:https://ijbms.mums.ac.ir/article_21478_c0f1f286f558745c6613d5d3209f6e7c.pdf

Internet

https://ijbms.mums.ac.ir/article_21478_c0f1f286f558745c6613d5d3209f6e7c.pdf

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