Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model.

Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model.

Intravesical therapy using Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the most established cancer immunotherapy for bladder cancer. However, its underlying mechanisms are unknown. Mycolic acid (MA), the most abundant lipid of the BCG cell wall, is suspected to be one of the essential acti...

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Bibliographic Details
Main Authors: Takayuki Yoshino, Jun Miyazaki, Takahiro Kojima, Shuya Kandori, Masanobu Shiga, Takashi Kawahara, Tomokazu Kimura, Takashi Naka, Hideyasu Kiyohara, Miyuki Watanabe, Sho Yamasaki, Hideyuki Akaza, Ikuya Yano, Hiroyuki Nishiyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209196

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https://doi.org/10.1371/journal.pone.0209196

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