Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in D...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162754/full |
| _version_ | 1797854985336127488 |
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| author | Yanan Cheng Yan Wang Ruili Yin Yongsong Xu Lijie Zhang Yuanyuan Zhang Longyan Yang Dong Zhao |
| author_facet | Yanan Cheng Yan Wang Ruili Yin Yongsong Xu Lijie Zhang Yuanyuan Zhang Longyan Yang Dong Zhao |
| author_sort | Yanan Cheng |
| collection | DOAJ |
| description | Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in DCM is of great significance to prevent or postpone the progression of DCM to heart failure. A growing body of evidence suggests that cardiomyocytes, immunocytes, and endothelial cells involve fibrogenic actions, however, cardiac fibroblasts, the main participants in collagen production, are situated in the most central position in cardiac fibrosis. In this review, we systematically elaborate the source and physiological role of myocardial fibroblasts in the context of DCM, and we also discuss the potential action and mechanism of cardiac fibroblasts in promoting fibrosis, so as to provide guidance for formulating strategies for prevention and treatment of cardiac fibrosis in DCM. |
| first_indexed | 2024-04-09T20:16:11Z |
| format | Article |
| id | doaj.art-2f6c1176315b472b888c7f9592b3eb1e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T20:16:11Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2f6c1176315b472b888c7f9592b3eb1e2023-03-31T07:51:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11627541162754Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathyYanan ChengYan WangRuili YinYongsong XuLijie ZhangYuanyuan ZhangLongyan YangDong ZhaoDiabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of myocardial fibrosis in DCM is of great significance to prevent or postpone the progression of DCM to heart failure. A growing body of evidence suggests that cardiomyocytes, immunocytes, and endothelial cells involve fibrogenic actions, however, cardiac fibroblasts, the main participants in collagen production, are situated in the most central position in cardiac fibrosis. In this review, we systematically elaborate the source and physiological role of myocardial fibroblasts in the context of DCM, and we also discuss the potential action and mechanism of cardiac fibroblasts in promoting fibrosis, so as to provide guidance for formulating strategies for prevention and treatment of cardiac fibrosis in DCM.https://www.frontiersin.org/articles/10.3389/fendo.2023.1162754/fulldiabetic cardiomyopathycardiac fibrosiscardiac myofibroblastscardiac fibroblastsimbalance of extracellular matrix synthesis and degradationdisorder of matrix metalloproteinases synthesis |
| spellingShingle | Yanan Cheng Yan Wang Ruili Yin Yongsong Xu Lijie Zhang Yuanyuan Zhang Longyan Yang Dong Zhao Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy Frontiers in Endocrinology diabetic cardiomyopathy cardiac fibrosis cardiac myofibroblasts cardiac fibroblasts imbalance of extracellular matrix synthesis and degradation disorder of matrix metalloproteinases synthesis |
| title | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| title_full | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| title_fullStr | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| title_full_unstemmed | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| title_short | Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| title_sort | central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy cardiac fibrosis cardiac myofibroblasts cardiac fibroblasts imbalance of extracellular matrix synthesis and degradation disorder of matrix metalloproteinases synthesis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1162754/full |
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