Microglia change from a reactive to an age-like phenotype with the time in culture

Microglia change from a reactive to an age-like phenotype with the time in culture

Age-related neurodegenerative diseases have been associated with chronic neuroinflammation and microglia activation. However, cumulative evidence supports that inflammation only occurs at an early stage once microglia change the endogenous characteristics with ageing and switch to irresponsive/senes...

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Bibliographic Details
Main Authors: Claudia eCaldeira, Ana Filipa Oliveira, Carolina eCunha, Ana Rita Vaz, Ana Sofia Falcão, Adelaide eFernandes, Dora eBrites
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Microglia
MicroRNAs
Phagocytosis
Migration
senescence
reactivity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00152/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00152/full

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