Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network

Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network

BackgroundVEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an adult-onset autoinflammatory condition resulting in severe, often treatment-refractory inflammation. Currently, there are no established treatment guidelines for VEXAS syndrome.ObjectivesTo assess the efficacy...

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Main Authors: Antonio Vitale, Flavia Leone, Valeria Caggiano, Andrea Hinojosa-Azaola, Eduardo Martín-Nares, Guillermo Arturo Guaracha-Basañez, Jiram Torres-Ruiz, Perla Ayumi Kawakami-Campos, Pravin Hissaria, Alicia Callisto, Mark Beecher, Lorenzo Dagna, Alessandro Tomelleri, Corrado Campochiaro, Micol Frassi, Francesca Crisafulli, Franco Franceschini, José Hernández-Rodríguez, Verónica Gómez-Caverzaschi, Olga Araújo, Paolo Sfriso, Sara Bindoli, Chiara Baggio, Jessica Sbalchiero, Jurgen Sota, Abdurrahman Tufan, Ibrahim Vasi, Matteo Piga, Alberto Cauli, Maria Antonietta D’Agostino, Amato De Paulis, Ilaria Mormile, Henrique A. Mayrink Giardini, Rafael Alves Cordeiro, Francesco Gavioli, Giuseppe Lopalco, Florenzo Iannone, Carlomaurizio Montecucco, Sara Monti, Guillermo Ruiz-Irastorza, Adriana Soto-Peleteiro, Paola Triggianese, Carmelo Gurnari, Ombretta Viapiana, Riccardo Bixio, Rosetta Vitetta, Edoardo Conticini, Francesco La Torre, Gaafar Ragab, Ezgi Deniz Batu, Andrés González-García, Mercedes Peña-Rodríguez, Monica Bocchia, Ewa Wiesik-Szewczyk, Karina Jahnz-Rózyk, Alejandra de-la-Torre, Alberto Balistreri, Bruno Frediani, Claudia Fabiani, Luca Cantarini
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
cDMARDs
clinical outcomes
autoinflammatory diseases
diagnosis
treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1539756/full

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https://www.frontiersin.org/articles/10.3389/fphar.2025.1539756/full

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