Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)-Local pO2 study in murine tumors.

Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)-Local pO2 study in murine tumors.

Hypoxia, an inevitable feature of locally advanced solid tumors, has been known as an adverse prognostic factor, a driver of an aggressive phenotype, and an unfavorable factor in therapies. Myo-inositol trispyrophosphate (ITPP) is a hemoglobin modifier known to both increase O2 release and normalize...

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Bibliographic Details
Main Authors: Martyna Krzykawska-Serda, Dariusz Szczygieł, Szymon Gaweł, Agnieszka Drzał, Małgorzata Szczygieł, Maciej M Kmieć, Andrzej Mackiewicz, Claudine Kieda, Martyna Elas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0285318

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https://doi.org/10.1371/journal.pone.0285318

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