The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized. J147 is a modified version of curcumin with superior bioavailability and stability. However, there is no report about the effects of J147 on pigmentation...

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Bibliographic Details
Main Authors: Jinpeng Lv, Ying Yang, Bingyi Jia, Siqi Li, Ximei Zhang, Rongyin Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
J147
hypopigmentary effects
melanosome transport
ERK pathway
MITF degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.783730/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.783730/full

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