Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking. Notably, cerebellar microglial activation appears to be a common feature in different types of ataxic patients and rode...

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Bibliographic Details
Main Authors: Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Pharmacological Research
Subjects:
Cerebellum
Microglia
Chemogenetic manipulation
Purkinje cell
Ataxia
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001299

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http://www.sciencedirect.com/science/article/pii/S1043661823001299

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